Chaotic asymptotic behaviour of the solutions of the Lighthill Whitham Richards equation

[EN] The phenomenon of chaos has been exhibited in mathematical nonlinear models that describe traffic flows, see, for instance (Li and Gao in Modern Phys Lett B 18(26-27):1395-1402, 2004; Li in Phys. D Nonlinear Phenom 207(1-2):41-51, 2005). At microscopic level, Devaney chaos and distributional chaos have been exhibited for some car-following models, such as the quick-thinking-driver model and the forward and backward control model (Barrachina et al. in 2015; Conejero et al. in Semigroup Forum, 2015). We present here the existence of chaos for the macroscopic model given by the Lighthill Whitham Richards equation.The authors are supported by MEC Project MTM2013-47093-P. The second and third authors are supported by GVA, Project PROMETEOII/2013/013Conejero, JA.; Martínez Jiménez, F.; Peris Manguillot, A.; Ródenas Escribá, FDA. (2016). Chaotic asymptotic behaviour of the solutions of the Lighthill Whitham Richards equation. Nonlinear Dynamics. 84(1):127-133. https://doi.org/10.1007/s11071-015-2245-4S127133841Albanese, A.A., Barrachina, X., Mangino, E.M., Peris, A.: Distributional chaos for strongly continuous semigroups of operators. Commun. Pure Appl. Anal. 12(5), 2069–2082 (2013)Aroza, J., Peris, A.: Chaotic behaviour of birth-and-death models with proliferation. J. Differ. Equ. Appl. 18(4), 647–655 (2012)Banasiak, J., Lachowicz, M.: Chaos for a class of linear kinetic models. C. R. Acad. Sci. Paris Sér. II 329, 439–444 (2001)Banasiak, J., Lachowicz, M.: Topological chaos for birth-and-death-type models with proliferation. Math. Models Methods Appl. Sci. 12(6), 755–775 (2002)Banasiak, J., Moszyński, M.: A generalization of Desch–Schappacher–Webb criteria for chaos. Discrete Contin. Dyn. Syst. 12(5), 959–972 (2005)Banasiak, J., Moszyński, M.: Dynamics of birth-and-death processes with proliferation—stability and chaos. Discrete Contin. Dyn. Syst. 29(1), 67–79 (2011)Barrachina, X., Conejero, J.A.: Devaney chaos and distributional chaos in the solution of certain partial differential equations. Abstr. Appl. Anal. Art. ID 457019, 11 (2012)Barrachina, X., Conejero, J.A., Murillo-Arcila, M., Seoane-Sepúlveda, J.B.: Distributional chaos for the forward and backward control traffic model (2015, preprint)Bayart, F., Matheron, É.: Dynamics of Linear Operators, Cambridge Tracts in Mathematics, vol. 179. Cambridge University Press, Cambridge (2009)Bayart, F., Matheron, É.: Mixing operators and small subsets of the circle. J Reine Angew. Math. (2015, to appear)Bermúdez, T., Bonilla, A., Conejero, J.A., Peris, A.: Hypercyclic, topologically mixing and chaotic semigroups on Banach spaces. Stud. Math. 170(1), 57–75 (2005)Bermúdez, T., Bonilla, A., Martínez-Giménez, F., Peris, A.: Li-Yorke and distributionally chaotic operators. J. Math. Anal. Appl. 373(1), 83–93 (2011)Bernardes Jr, N.C., Bonilla, A., Müller, V., Peris, A.: Distributional chaos for linear operators. J. Funct. Anal. 265(9), 2143–2163 (2013)Brackstone, M., McDonald, M.: Car-following: a historical review. Transp. Res. Part F Traffic Psychol. Behav. 2(4), 181–196 (1999)Conejero, J.A., Lizama, C., Rodenas, F.: Chaotic behaviour of the solutions of the Moore–Gibson–Thompson equation. Appl. Math. Inf. Sci. 9(5), 1–6 (2015)Conejero, J.A., Mangino, E.M.: Hypercyclic semigroups generated by Ornstein-Uhlenbeck operators. Mediterr. J. Math. 7(1), 101–109 (2010)Conejero, J.A., Müller, V., Peris, A.: Hypercyclic behaviour of operators in a hypercyclic $$C_0$$ C 0 -semigroup. J. Funct. Anal. 244, 342–348 (2007)Conejero, J.A., Murillo-Arcila, M., Seoane-Sepúlveda, J.B.: Linear chaos for the quick-thinking-driver model. Semigroup Forum (2015). doi: 10.1007/s00233-015-9704-6Conejero, J.A., Peris, A., Trujillo, M.: Chaotic asymptotic behavior of the hyperbolic heat transfer equation solutions. Int. J. Bifur. Chaos Appl. Sci. Eng. 20(9), 2943–2947 (2010)Conejero, J.A., Rodenas, F., Trujillo, M.: Chaos for the hyperbolic bioheat equation. Discrete Contin. Dyn. Syst. 35(2), 653–668 (2015)Desch, W., Schappacher, W., Webb, G.F.: Hypercyclic and chaotic semigroups of linear operators. Ergod. Theory Dyn. Syst. 17(4), 793–819 (1997)Engel, K.-J., Nagel, R.: One-parameter semigroups for linear evolution equations, Graduate Texts in Mathematics, vol. 194. Springer, New York (2000). With contributions by S. Brendle, M. Campiti, T. Hahn, G. Metafune, G. Nickel, D. Pallara, C. Perazzoli, A. Rhandi, S. Romanelli and R. SchnaubeltGrosse-Erdmann, K.-G., Peris Manguillot, A.: Linear Chaos. Universitext. Springer, London (2011)Herzog, G.: On a universality of the heat equation. Math. Nachr. 188, 169–171 (1997)Li, K., Gao, Z.: Nonlinear dynamics analysis of traffic time series. Modern Phys. Lett. B 18(26–27), 1395–1402 (2004)Li, T.: Nonlinear dynamics of traffic jams. Phys. D Nonlinear Phenom. 207(1–2), 41–51 (2005)Lustri, C.: Continuum Modelling of Traffic Flow. Special Topic Report. Oxford University, Oxford (2010)Lighthill, M.J., Whitham, G.B.: On kinematic waves. II. A theory of traffic flow on long crowded roads. Proc. R. Soc. Lond. Ser. A. 229, 317–345 (1955)Maerivoet, S., De Moor, B.: Cellular automata models of road traffic. Phys. Rep. 419(1), 1–64 (2005)Mangino, E.M., Peris, A.: Frequently hypercyclic semigroups. Stud. Math. 202(3), 227–242 (2011)Murillo-Arcila, M., Peris, A.: Strong mixing measures for linear operators and frequent hypercyclicity. J. Math. Anal. Appl. 398, 462–465 (2013)Murillo-Arcila, M., Peris, A.: Strong mixing measures for $$C_0$$ C 0 -semigroups. Rev. R. Acad. Cienc. Exactas Fís. Nat. Ser. A Math. RACSAM 109(1), 101–115 (2015)Pazy, A.: Semigroups of Linear Operators and Applications to Partial Differential Equations, Applied Mathematical Sciences, vol. 44. Springer, New York (1983)Protopopescu, V., Azmy, Y.Y.: Topological chaos for a class of linear models. Math. Models Methods Appl. Sci. 2(1), 79–90 (1992)Richards, P.I.: Shock waves on the highway. Oper. Res. 4, 42–51 (1956

Linear chaos for the Quick-Thinking-Driver model

The final publication is available at Springer via http://dx.doi.org/10.1007/s00233-015-9704-6In recent years, the topic of car-following has experimented an increased importance in traffic engineering and safety research. This has become a very interesting topic because of the development of driverless cars (Google driverless cars, http://en.wikipedia.org/wiki/Google_driverless_car).Driving models which describe the interaction between adjacent vehicles in the same lane have a big interest in simulation modeling, such as the Quick-Thinking-Driver model. A non-linear version of it can be given using the logistic map, and then chaos appears. We show that an infinite-dimensional version of the linear model presents a chaotic behaviour using the same approach as for studying chaos of death models of cell growth.The authors were supported by a grant from the FPU program of MEC and MEC Project MTM2013-47093-P.Conejero, JA.; Murillo Arcila, M.; Seoane-Sepúlveda, JB. (2016). Linear chaos for the Quick-Thinking-Driver model. Semigroup Forum. 92(2):486-493. https://doi.org/10.1007/s00233-015-9704-6S486493922Aroza, J., Peris, A.: Chaotic behaviour of birth-and-death models with proliferation. J. Differ. Equ. Appl. 18(4), 647–655 (2012)Banasiak, J., Lachowicz, M.: Chaos for a class of linear kinetic models. C. R. Acad. Sci. Paris Série II 329, 439–444 (2001)Banasiak, J., Lachowicz, M.: Topological chaos for birth-and-death-type models with proliferation. Math. Models Methods Appl. Sci. 12(6), 755–775 (2002)Banasiak, J., Lachowicz, M., Moszyński, M.: Topological chaos: when topology meets medicine. Appl. Math. Lett. 16(3), 303–308 (2003)Banasiak, J., Moszyński, M.: A generalization of Desch–Schappacher–Webb criteria for chaos. Discret. Contin. Dyn. Syst. 12(5), 959–972 (2005)Banasiak, J., Moszyński, M.: Dynamics of birth-and-death processes with proliferation–stability and chaos. Discret. Contin. Dyn. Syst. 29(1), 67–79 (2011)Banks, J., Brooks, J., Cairns, G., Davis, G., Stacey, P.: On Devaney’s definition of chaos. Am. Math. Mon. 99(4), 332–334 (1992)Barrachina, X., Conejero, J.A.: Devaney chaos and distributional chaos in the solution of certain partial differential equations. Abstr. Appl. Anal. 457,019, 11 (2012)Bermúdez, T., Bonilla, A., Martínez-Giménez, F., Peris, A.: Li-Yorke and distributionally chaotic operators. J. Math. Anal. Appl. 373(1), 83–93 (2011)Brackstone, M., McDonald, M.: Car-following: a historical review. Transp. Res. Part F 2(4), 181–196 (1999)Brzeźniak, Z., Dawidowicz, A.L.: On periodic solutions to the von Foerster–Lasota equation. Semigroup Forum 78, 118–137 (2009)Chandler, R.E., Herman, R., Montroll, E.W.: Traffic dynamics: studies in car following. Op. Res. 6, 165–184 (1958)Chung, C.C., Gartner, N.: Acceleration noise as a measure of effectiveness in the operation of traffic control systems. Operations Research Center. Massachusetts Institute of Technology. Cambridge (1973)CNN (2014) Driverless car tech gets serious at CES. http://edition.cnn.com/2014/01/09/tech/innovation/self-driving-cars-ces/ . Accessed 7 Apr 2014Conejero, J.A., Rodenas, F., Trujillo, M.: Chaos for the hyperbolic bioheat equation. Discret. Contin. Dyn. Syst. 35(2), 653–668 (2015)DARPA Grand Challenge. http://en.wikipedia.org/wiki/2005_DARPA_Grand_Challenge#2005_Grand_Challengede Laubenfels, R., Emamirad, H., Protopopescu, V.: Linear chaos and approximation. J. Approx. Theory 105(1), 176–187 (2000)Desch, W., Schappacher, W., Webb, G.F.: Hypercyclic and chaotic semigroups of linear operators. Ergod. Theory Dyn. Syst. 17(4), 793–819 (1997)El Mourchid, S.: The imaginary point spectrum and hypercyclicity. Semigroup Forum 73(2), 313–316 (2006)El Mourchid, S., Metafune, G., Rhandi, A., Voigt, J.: On the chaotic behaviour of size structured cell populations. J. Math. Anal. Appl. 339(2), 918–924 (2008)El Mourchid, S., Rhandi, A., Vogt, H., Voigt, J.: A sharp condition for the chaotic behaviour of a size structured cell population. Differ. Integral Equ. 22(7–8), 797–800 (2009)Engel, K.-J., Nagel, R.: One-Parameter Semigroups for Linear Evolution Equations. Graduate Texts in Mathematics, vol. 194. Springer, New York, 2000. With contributions by Brendle S., Campiti M., Hahn T., Metafune G., Nickel G., Pallara D., Perazzoli C., Rhandi A., Romanelli S., and Schnaubelt RGodefroy, G., Shapiro, J.H.: Operators with dense, invariant, cyclic vector manifolds. J. Funct. Anal. 98(2), 229–269 (1991)Greenshields, B.D.: The photographic method of studying traffic behavior. In: Proceedings of the 13th Annual Meeting of the Highway Research Board, pp. 382–399 (1934)Greenshields, B.D.: A study of traffic capacity. In: Proceedings of the 14th Annual Meeting of the Highway Research Board, pp. 448–477 (1935)Grosse-Erdmann, K.G., Peris Manguillot, A.: Linear Chaos. Universitext. Springer, London (2011)Herman, R., Montroll, E.W., Potts, R.B., Rothery, R.W.: Traffic dynamics: analysis of stability in car following. Op. Res. 7, 86–106 (1959)Helly, W.: Simulation of Bottleneckes in Single-Lane Traffic Flow. Research Laboratories, General Motors. Elsevier, New York (1953)Li, T.: Nonlinear dynamics of traffic jams. Phys. D 207(1–2), 41–51 (2005)Lo, S.C., Cho, H.J.: Chaos and control of discrete dynamic traffic model. J. Franklin Inst. 342(7), 839–851 (2005)Martínez-Giménez, F., Oprocha, P., Peris, A.: Distributional chaos for backward shifts. J. Math. Anal. Appl. 351(2), 607–615 (2009)Pipes, L.A.: An operational analysis of traffic dynamics. J. Appl. Phys. 24, 274–281 (1953

Objective comparison of methods to decode anomalous diffusion

Deviations from Brownian motion leading to anomalous diffusion are found in transport dynamics from quantum physics to life sciences. The characterization of anomalous diffusion from the measurement of an individual trajectory is a challenging task, which traditionally relies on calculating the trajectory mean squared displacement. However, this approach breaks down for cases of practical interest, e.g., short or noisy trajectories, heterogeneous behaviour, or non-ergodic processes. Recently, several new approaches have been proposed, mostly building on the ongoing machine-learning revolution. To perform an objective comparison of methods, we gathered the community and organized an open competition, the Anomalous Diffusion challenge (AnDi). Participating teams applied their algorithms to a commonly-defined dataset including diverse conditions. Although no single method performed best across all scenarios, machine-learning-based approaches achieved superior performance for all tasks. The discussion of the challenge results provides practical advice for users and a benchmark for developers

Is adenomyosis the neglected phenotype of an endomyometrial dysfunction syndrome?

Since the dissociation between adenomyoma and endometriosis in the 1920s and the laparoscopic progress in the diagnosis and surgery of endometriosis, the literature has been greatly focused on the disease endometriosis. The study of adenomyosis, on the other hand, has been neglected as the diagnosis remained based on hysterectomy specimens. However, since the introduction of magnetic resonance and sonographic imaging techniques in the 1980s, the myometrial junctional zone has been identified as a third uterine zone and interest in adenomyosis was renewed. This has also been the start for the interest in the role of the myometrial junctional zone dysfunction and adenomyosis in reproductive and obstetrical disorders

Glutamine supplementation

Intravenous glutamine supplementation is standard care when parenteral nutrition is given for critical illness. There are data of a reduced mortality when glutamine supplementation is given. In addition, standard commercial products for parenteral nutrition do not contain any glutamine due to glutamine instability in aqueous solutions. For the majority of critical ill patients who are fed enterally, the available evidence is insufficient to recommend glutamine supplementation. Standard formulation of enteral nutrition contains some glutamine: 2-4 g/L. However, this dose is insufficient to normalize glutamine plasma concentration

Nutritional therapy and infectious diseases: a two-edged sword

The benefits and risks of nutritional therapies in the prevention and management of infectious diseases in the developed world are reviewed. There is strong evidence that early enteral feeding of patients prevents infections in a variety of traumatic and surgical illnesses. There is, however, little support for similar early feeding in medical illnesses. Parenteral nutrition increases the risk of infection when compared to enteral feeding or delayed nutrition. The use of gastric feedings appears to be as safe and effective as small bowel feedings. Dietary supplementation with glutamine appears to lower the risk of post-surgical infections and the ingestion of cranberry products has value in preventing urinary tract infections in women

In praise of arrays

Microarray technologies have both fascinated and frustrated the transplant community since their introduction roughly a decade ago. Fascination arose from the possibility offered by the technology to gain a profound insight into the cellular response to immunogenic injury and the potential that this genomic signature would be indicative of the biological mechanism by which that stress was induced. Frustrations have arisen primarily from technical factors such as data variance, the requirement for the application of advanced statistical and mathematical analyses, and difficulties associated with actually recognizing signature gene-expression patterns and discerning mechanisms. To aid the understanding of this powerful tool, its versatility, and how it is dramatically changing the molecular approach to biomedical and clinical research, this teaching review describes the technology and its applications, as well as the limitations and evolution of microarrays, in the field of organ transplantation. Finally, it calls upon the attention of the transplant community to integrate into multidisciplinary teams, to take advantage of this technology and its expanding applications in unraveling the complex injury circuits that currently limit transplant survival

Preliminary safety and efficacy of first-line pertuzumab combined with trastuzumab and taxane therapy for HER2-positive locally recurrent or metastatic breast cancer (PERUSE).

BACKGROUND: Pertuzumab combined with trastuzumab and docetaxel is the standard first-line therapy for HER2-positive metastatic breast cancer, based on results from the phase III CLEOPATRA trial. PERUSE was designed to assess the safety and efficacy of investigator-selected taxane with pertuzumab and trastuzumab in this setting. PATIENTS AND METHODS: In the ongoing multicentre single-arm phase IIIb PERUSE study, patients with inoperable HER2-positive advanced breast cancer (locally recurrent/metastatic) (LR/MBC) and no prior systemic therapy for LR/MBC (except endocrine therapy) received docetaxel, paclitaxel or nab-paclitaxel with trastuzumab [8\u2009mg/kg loading dose, then 6\u2009mg/kg every 3\u2009weeks (q3w)] and pertuzumab (840\u2009mg loading dose, then 420\u2009mg q3w) until disease progression or unacceptable toxicity. The primary end point was safety. Secondary end points included overall response rate (ORR) and progression-free survival (PFS). RESULTS: Overall, 1436 patients received at least one treatment dose (initially docetaxel in 775 patients, paclitaxel in 589, nab-paclitaxel in 65; 7 discontinued before starting taxane). Median age was 54\u2009years; 29% had received prior trastuzumab. Median treatment duration was 16\u2009months for pertuzumab and trastuzumab and 4\u2009months for taxane. Compared with docetaxel-containing therapy, paclitaxel-containing therapy was associated with more neuropathy (all-grade peripheral neuropathy 31% versus 16%) but less febrile neutropenia (1% versus 11%) and mucositis (14% versus 25%). At this preliminary analysis (52 months' median follow-up), median PFS was 20.6 [95% confidence interval (CI) 18.9-22.7] months overall (19.6, 23.0 and 18.1\u2009months with docetaxel, paclitaxel and nab-paclitaxel, respectively). ORR was 80% (95% CI 78%-82%) overall (docetaxel 79%, paclitaxel 83%, nab-paclitaxel 77%). CONCLUSIONS: Preliminary findings from PERUSE suggest that the safety and efficacy of first-line pertuzumab, trastuzumab and taxane for HER2-positive LR/MBC are consistent with results from CLEOPATRA. Paclitaxel appears to be a valid alternative taxane backbone to docetaxel, offering similar PFS and ORR with a predictable safety profile. CLINICALTRIALS.GOV: NCT01572038